International Academic Journal of Science and Engineering

  • ISSN 2454-3896

A new method to determine cluster heads based on principal component analysis in gene regulation process

Masoume Maghsoodi

Abstract: There is a vital chemical in the cells of every living being which is called nucleic acid; it makes up the genetic material of cells. The genetic material is a factor which transfers the characteristics of a species from one generation to another. The nucleic acids in cells have two types: RNA and DNA. The genetic mutations or environmental toxins cause the cells react differently; the reaction is mostly performed in undesirable way. Therefore, the identification of gene regulation process is applicable not only to understand the disease, but also to provide appropriate treatment. However, this study aimed to increase the efficiency of gene regulation network using new methods of determining cluster heads based on principal component analysis in gene regulation process. After creating the network of gene regulation, if we connect different clusters and connect the networks of each cluster, an appropriate agent should be selected for each cluster and the agents should be connected to each other. Then, the network is made among these agents. The results of tests showed that the proposed method improved detection rate.

Keywords: Principal Component Analysis, Cluster Heads, Gene Regulation Network Inference

Page: 104-111

Volume 1, Issue 1, 2014